Animal Models of Human Disease, Volume 100 (Molecular by Min Kyung-Tai, Karen Chang PDF

By Min Kyung-Tai, Karen Chang

ISBN-10: 0123848784

ISBN-13: 9780123848789

Animal experiments have contributed a lot to our realizing of mechanisms of ailment and are important for deciding on new treatments. This quantity experiences the newest study and advancements during this box. * Discusses new discoveries, ways, and ideas * Contributions from best students and specialists * Reference advisor for researchers considering molecular biology and similar fields

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Additional info for Animal Models of Human Disease, Volume 100 (Molecular Biology and Translational Science)

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The epithelial cells exhibit papillary hyperplasia with atypia displayed in the FGF8b transgenic mice. 122 In addition to late age-related development of typical adenocarcinoma, the FGF8b/Ptenþ/À mice also displays a low incidence of mucinous adenocarcinoma, a rare variant type of human prostatic adenocarcinoma. Thus, the results demonstrate the cooperation between FGF8b overexpression and Pten deficiency in prostate tumorigenesis. 124,125 Forced expression of FGFR1 in premalignant rat prostate tumor cells, DT3 from the Dunning 3327 tumors, accelerates progression of the cells to malignancy in a time-dependent manner.

122 In addition to late age-related development of typical adenocarcinoma, the FGF8b/Ptenþ/À mice also displays a low incidence of mucinous adenocarcinoma, a rare variant type of human prostatic adenocarcinoma. Thus, the results demonstrate the cooperation between FGF8b overexpression and Pten deficiency in prostate tumorigenesis. 124,125 Forced expression of FGFR1 in premalignant rat prostate tumor cells, DT3 from the Dunning 3327 tumors, accelerates progression of the cells to malignancy in a time-dependent manner.

1 null mice are viable, but exhibit defects in prostate organ structure and secretory function in young adult males. 1 mutant mice develop prostatic epithelial hyperplasia, dysplasia, and low- to high-grade PIN. 1 null mice develop low- to high-grade PIN lesions, with the features of perturbed basal cell layer, disrupted stroma, and compromised expression of prostate epithelial differentiation markers. 1 has tumor suppressor activity. 1 are not fully understood. 1/Pten double mutant mice display an increased incidence of highgrade PIN by 6 months of age.

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Animal Models of Human Disease, Volume 100 (Molecular Biology and Translational Science) by Min Kyung-Tai, Karen Chang


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